The hottest soft capsule preparation has become a

2022-08-17
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Soft capsule preparation has become a new trend in pharmaceutical packaging

soft capsule health food is very popular abroad, with about 2000 varieties. China imports more than 200 million dollars of soft capsules from abroad every year. At the same time, the domestic production scale is gradually expanding. Although many domestic health food has existed in the form of oral liquid for a long time, soft capsule health food, as a rising star, is gradually becoming the "boss" of the health food family with its irreplaceable advantages in recent years. Soft capsules have become a new trend in packaging. The popular packaging in the international market is mainly soft capsules, which are both portable and hygienic. At present, there is no lack of capsules in the packaging used in China, but there is a gap with the international market in terms of appearance and packaging quality. Especially in terms of visual impact, it can't cause people's desire to buy or appetite. Advertising is often limited to long wordings and an exaggerated headline. With the application of new soft capsule production technology, the packaging of health products is bound to be greatly improved in terms of materials, colors, shapes and so on, which adds a weight to the international market

- advantages of soft capsule preparations

at present, there are many kinds of drugs and cosmetics (such as essence) in this form of packaging in the international market, which have some special advantages

the appearance of the product is novel and attractive. The packaging of this granular capsule has good taste for drugs, is easy to swallow and prevents counterfeiting. The appearance is different, colorful and attractive, which is very attractive and novel to consumers. For cosmetics, different shapes can also express different themes, and can become unique gifts for friends and relatives to express friendship, love and blessings

the product will not cause secondary pollution in use. Capsules, such as skin and eye medicines or cosmetics, have small packaging, and their net content is designed as a single dosage. In this way, consumers do not have to reuse one capsule each time, so as to avoid possible secondary pollution during the use of the product and ensure that the product used by consumers every time is clean

it is safe to carry and easy to use. The packaging characteristics of such products make it possible for people going out to carry them separately according to their consumption; In addition, its packaging is not easy to break, and it is also very safe to carry; While it is suitable for consumers' daily home use, it is more suitable for people to use when going out on vacation, traveling and field work

- Preparation Technology of soft capsules

in the production of cosmetic soft capsules, capsules are prepared by encapsulating the contents in the capsule skin with capsule pressing equipment. Strictly speaking, the preparation of capsules should include the preparation of capsule skin and the preparation of contents. The encapsulation materials of capsule cosmetics are mostly high molecular organic substances, commonly used are natural products such as gelatin, Arabic gum, agar, and synthetic high molecular compounds such as polypropylene, polyvinyl alcohol, polyvinylpyrrolidone, etc. At present, compound gelatin is the most widely used capsule products at home and abroad, which is made by boiling pig bones. Gelatin, as a capsule material, is characterized by high safety (mostly food grade products), low cost, convenient processing, fast biodegradation and easy dissolution in water. Such materials will not cause pollution and harm to the environment. But the disadvantage is that some gelatin usually has some odor. If this odor is not cleaned, it is easy to bring it into the packaged product. Therefore, gelatin needs to be pre refined before use to remove the odor. In addition to adding a certain proportion of water in the capsule formula, a certain amount of polyol should also be added as a moisturizer to endow and maintain the softness of the capsule and prevent the capsule from hardening. In addition, a certain amount of preservatives should be added to the formula to prevent microorganisms from polluting the contents during the storage of the capsule. Capsules made of water-soluble polymer materials such as composite gelatin have certain requirements for the contents they contain. If the content is homogeneous, it must be a non-aqueous formula, otherwise the capsule skin will be deformed and broken; If the content is an emulsion, its external phase must be a non-aqueous phase, or an anhydrous or low water lotion. For the convenience of processing and encapsulation, the viscosity of the content should not be too large, and a stone should cause thousands of waves. In short, the formulation of the contents should be consistent with the requirements of rubber materials to avoid effective leakage. At present, the homogeneous all oil formula with silicone as the main raw material is widely used, which has the advantages of transparency, stability and no interaction with the capsule skin. However, due to the absence of water in the formula, the occasions used are limited. How to choose volatile oil and its proportion is the key to prepare a good oil formula

for the production of soft capsules of drugs and health products, rubber materials are strictly required. At present, the most mature is edible gelatin. However, how to purify the active substance of traditional Chinese medicine and whether the component is water-based or oil-based are key issues. Because the gelatin coating can only be coated with oil substances. For water-based components, solid dispersion technology is needed. The drug is made into powder by freeze-drying method (such as royal jelly freeze-dried powder), and then dispersed into peg with molecular weight of 400-40000 to form a slurry, and then coated with gelatin into soft capsules. However, another problem will appear at this time, that is, PEG itself also has high moisture absorption, which will inevitably affect the tightness of gelatin interface. Domestic manufacturers have recently proposed a method to thicken the skin of soft capsules, but this is subject to equipment performance and cost constraints

-- there is great potential for developing soft capsules

soft hr30t capsules are also called elastic capsules, and their elasticity depends on the proportion of gelatin, plasticizer and water in the capsule shell. The earliest soft capsule preparations were weishengyi A and D capsules. Since 1933, the rotary die encapsulation machine was invented, which greatly increased the output and significantly reduced the cost. European and American countries have adopted it one after another, and constantly improved the mechanical equipment, so that the capsule can not only fill liquid and paste soft drugs, but also develop to fill solid powder, and the variety and output continue to increase. Soft capsule preparation is more and more favored by consumers because of its good bioavailability, sealing, safety, drug stability, accurate dosage, beautiful appearance, easy to carry and use and other characteristics. It has broad market prospects and great development potential at home and abroad

soft capsules are widely used in medicine. According to clinical needs, their products have various sizes and specifications, different shapes, and different colors such as monochrome and multicolor. Besides medicine, it has also been widely used in household chemicals, food industry, chemistry and other industrial fields. Skin care products packed in soft capsules, because of its good airtightness, not easy to deteriorate, long storage time, one capsule a day, easy to carry and use, have quickly become popular all over the world, and the price is much higher than that of ordinary skin care products

in recent years, the world has attached great importance to the development and research of soft capsules, and soft capsule preparations are also developing. The United States is the world's largest soft capsule manufacturer, with nearly 20 subsidiaries in more than 10 countries, accounting for about 70% of the world's soft capsule Market. German and British companies also have large sales. At present, the global sales of soft capsules is about US $400million, of which nutritious products account for a large proportion, up to more than 70% at most. It has a broad market in developed countries

because soft capsule preparation is a relatively difficult dosage form to produce, the water-based waterproof materials often used in the technical design market mainly include: acrylic waterproof coating, JS polymer cement waterproof coating and series polymer cement waterproof mortar, etc., which have high preparation requirements and strong professionalism, so there are few pharmaceutical factories engaged in the production of soft capsule preparation. In foreign countries, this product is undertaken by professional soft capsule manufacturers. Pharmaceutical factories or other factories carry out business in the form of entrusted processing, and their prescription technology and patents are confidential, so the production of soft capsule preparations is affected to a certain extent

China began to produce soft capsules in the 1960s. Before the 1970s, the production equipment of soft capsule preparations was backward, the product quality was poor, and the production stagnated. In the late 1970s, China began to introduce and digest foreign more advanced mold transfer machines and equipment, and the production capacity and technical level have been greatly improved. At present, China has more than 70 soft capsule manufacturing machines, accounting for about 10% of the world, half of which are imported from the United States, Japan, Britain, Italy, Australia and other countries. There are 4 manufacturers. With the continuous development of aerogel gel industry, there are more than 0 manufacturers, with an annual output of more than 7 billion grains, accounting for about 10% of the world, but there are few varieties, only more than 40, accounting for about 1% of the world. The varieties are also relatively monotonous. The main production varieties include Maitong capsule, vitamin E capsule, duosekang capsule, etc., and the factories repeat the production. In addition, compared with foreign countries, there are still many gaps in the development and research of appearance, varieties for different purposes, product quality and process prescription

in recent years, China has paid more attention to the production and development of soft capsule preparations, and has made some progress. The production scope has also developed from simple western medicine preparations to Chinese patent medicine preparations. Nine Chinese medicine factories have produced soft capsules of traditional Chinese medicine preparations and put them on the market, while others have developed soft capsules of nourishing nutrients. In addition, bath pills for household washing have also been successfully developed, and soft capsules for skin care have also been produced in Guangdong and other places. Some soft capsule products produced in China are also exported to Japan, the United States, Singapore and other countries and regions. In particular, Chinese patent medicine and nutritional supplements are welcomed by users at home and abroad, and the market sales prospects are promising

however, from the current domestic market, soft capsule preparations are far from meeting the market demand in terms of variety, quantity, purpose, appearance, etc., and there is still considerable room for development. For example, royal jelly products are mainly sold in bottles and freeze-dried powder in the domestic market at present, while most foreign countries wrap royal jelly in soft capsules, which can make its quality stable, dosage accurate, beautiful appearance, and convenient to carry and take. Another example is skin care soft capsules. Most of the products sold in the domestic market are imported from the United States, France, South Korea and other countries, and most of the domestic products are produced by joint ventures. With the increasing improvement of people's living standards, the market demand for various soft capsule preparations is also increasing, and the development of such products has broad prospects

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